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Early expression of GluN2A-containing NMDA receptors in a model of fragile X syndrome

https://doi.org/10.1152/jn.00406.2023

Banke, Tue G; Traynelis, Stephen F; Barria, Andres (April 2024, Journal of Neurophysiology)

NMDA receptors (NMDARs) play important roles in synaptic transmission and are involved in multiple neurological disorders. During development, GluN2A in the forebrain becomes incorporated into previously GluN2B-dominated NMDARs, leading to the “GluN2A/GluN2B ratio switch.” This is a crucial step for normal brain development. Here we present findings indicating that GluN2A expression occurs earlier in the fragile X mouse and this could be an underlying factor contributing to the pathology found in the fragile X model.
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NMDA receptor blockade ameliorates abnormalities of spike firing of subthalamic nucleus neurons in a parkinsonian nonhuman primate

https://doi.org/10.1002/jnr.24230

Bhattacharya, Subhrajit; Ma, Yuxian; Dunn, Amy R.; Bradner, Joshua M.; Scimemi, Annalisa; Miller, Gary W.; Traynelis, Stephen F.; Wichmann, Thomas (July 2018, Journal of Neuroscience Research)

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Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates

https://doi.org/10.1016/j.celrep.2017.12.095

Singh, Arun; Jenkins, Meagan A.; Burke, Kenneth J.; Beck, Goichi; Jenkins, Andrew; Scimemi, Annalisa; Traynelis, Stephen F.; Papa, Stella M. (January 2018, Cell Reports)

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